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RGS18 [plasma membrane]
Stable Identifier
R-HSA-939799
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 18, RGS18_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS18 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NS28 RGS18
Gene Names
RGS18, RGS13
Chain
chain:1-235
Reference Genes
BioGPS Gene:64407 RGS18
COSMIC (genes):RGS18 RGS18
CTD Gene:64407 RGS18
dbSNP Gene:64407 RGS18
ENSEMBL:ENSG00000150681 RGS18
ENSEMBL_homo_sapiens_GENE:ENSG00000150681.10 RGS18
HGNC:14261 RGS18
KEGG Gene (Homo sapiens):64407 RGS18
Monarch:64407 RGS18
NCBI Gene:64407 RGS18
OMIM:607192 RGS18
UCSC:Q9NS28 RGS18
Reference Transcript
RefSeq:NM_130782.2 RGS18
Other Identifiers
11729758_at
11729759_at
16675278
223809_PM_at
223809_at
2372721
2372722
2372723
2372724
2372725
2372726
2372727
2372732
2372734
2372735
2372737
2372739
46850_r_at
64407
7908376
A_14_P119196
A_14_P202283
A_23_P302550
GE62454
GO:0003824
GO:0003924
GO:0005096
GO:0005515
GO:0005737
GO:0005886
GO:0007186
GO:0008277
GO:0009968
GO:0016787
GO:0023052
GO:0098772
HMNXSV003026921
ILMN_2101278
PH_hs_0025810
TC01001619.hg
g8885627_3p_at
Participates
as a member of
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
Inferred To
rgs-10 [plasma membrane]
(Caenorhabditis elegans)
rgs-6 [plasma membrane]
(Caenorhabditis elegans)
rgs18 [plasma membrane]
(Xenopus tropicalis)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs-3 [plasma membrane]
(Caenorhabditis elegans)
RGS2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
rgs-8.1 [plasma membrane]
(Caenorhabditis elegans)
RGS18 [plasma membrane]
(Bos taurus)
RGS18 [plasma membrane]
(Canis familiaris)
RGS18 [plasma membrane]
(Dictyostelium discoideum)
RGS18 [plasma membrane]
(Gallus gallus)
RGS18 [plasma membrane]
(Sus scrofa)
rgs-11 [plasma membrane]
(Caenorhabditis elegans)
rgs-4 [plasma membrane]
(Caenorhabditis elegans)
rgs-7 [plasma membrane]
(Caenorhabditis elegans)
Rgs18 [plasma membrane]
(Mus musculus)
Rgs18 [plasma membrane]
(Rattus norvegicus)
Homologues of RGS18 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS18 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RGS18 [plasma membrane]
(Saccharomyces cerevisiae)
rgs-9 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_570138.1
Guide to Pharmacology - Targets
2807
OpenTargets
ENSG00000150681
GeneCards
Q9NS28
HPA
ENSG00000150681-RGS18
Ensembl
ENSG00000150681
,
ENST00000367460
,
ENSP00000356430
PRO
Q9NS28
Pharos - Targets
Q9NS28
Orphanet
24856
PDB
2OWI
,
2DLV
,
2JM5
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