IRAK2 induces TRAF6 oligomerization

Stable Identifier
R-HSA-936963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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IRAK2 induces TRAF6 oligomerization
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The mechanism by which IRAK-2 induces TRAF6 E3 ligase activity remains to be deciphered, but one possibility is that IRAK-2 may direct TRAF6 oligomerization.

Literature References
PubMed ID Title Journal Year
17878161 IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

Keating, SE, Maloney, GM, Moran, EM, Bowie, AG

J Biol Chem 2007
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Orthologous Events
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IRAK2 induces TRAF6 oligomerization (Drosophila melanogaster)
IRAK2 induces TRAF6 oligomerization (Gallus gallus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
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IRAK2 induces TRAF6 oligomerization (Sus scrofa)
IRAK2 induces TRAF6 oligomerization (Xenopus tropicalis)
TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
Shamovsky, V  (2010-08-25)