IRAK2 induces TRAF6 oligomerization

Stable Identifier
R-HSA-936963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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IRAK2 induces TRAF6 oligomerization
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The mechanism by which IRAK-2 induces TRAF6 E3 ligase activity remains to be deciphered, but one possibility is that IRAK-2 may direct TRAF6 oligomerization.
Literature References
PubMed ID Title Journal Year
17878161 IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

Maloney, GM, Bowie, AG, Keating, SE, Moran, EM

J Biol Chem 2007
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Orthologous Events
IRAK2 induces TRAF6 oligomerization (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Drosophila melanogaster)
IRAK2 induces TRAF6 oligomerization (Gallus gallus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
Shamovsky, V  (2010-08-25)
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