Reactome | CYBRD1:Heme reduces Fe3+ to Fe2+

CYBRD1:Heme reduces Fe3+ to Fe2+

Stable Identifier

R-HSA-917805

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Reduction of extracellular Fe3+

ReviewStatus

5/5

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Cytochrome b reductase 1 not only reduces ferrous iron in the brush-border membrane but also in the airways. It is upregulated on iron starvation. However, its electron donor molecule is still unknown (Oakhill et al, 2007; Turi et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16510471	Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells McKie, AT, Ghio, AJ, Piantadosi, CA, Mamo, LB, Crissman, K, Wang, X, Nozik-Grayck, E, Turi, JL	Am J Physiol Lung Cell Mol Physiol	2006
18194661	Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism McKie, AT, Cammack, R, Gareta, EG, Oakhill, JS, Marritt, SJ	Biochim Biophys Acta	2008