CYBRD1:Heme reduces Fe3+ to Fe2+

Stable Identifier
R-HSA-917805
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Reduction of extracellular Fe3+
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Cytochrome b reductase 1 not only reduces ferrous iron in the brush-border membrane but also in the airways. It is upregulated on iron starvation. However, its electron donor molecule is still unknown (Oakhill et al, 2007; Turi et al, 2006).

Literature References
PubMed ID Title Journal Year
16510471 Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells

McKie, AT, Ghio, AJ, Piantadosi, CA, Mamo, LB, Crissman, K, Wang, X, Nozik-Grayck, E, Turi, JL

Am J Physiol Lung Cell Mol Physiol 2006
18194661 Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism

McKie, AT, Cammack, R, Gareta, EG, Oakhill, JS, Marritt, SJ

Biochim Biophys Acta 2008
Participants
Participates
Catalyst Activity

oxidoreductase activity, acting on metal ions of CYBRD1:Heme [plasma membrane]

Orthologous Events
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