CYBRD1:Heme reduces Fe3+ to Fe2+

Stable Identifier
R-HSA-917805
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Reduction of extracellular Fe3+
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytochrome b reductase 1 not only reduces ferrous iron in the brush-border membrane but also in the airways. It is upregulated on iron starvation. However, its electron donor molecule is still unknown (Oakhill et al, 2007; Turi et al, 2006).

Literature References
PubMed ID Title Journal Year
18194661 Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism

Oakhill, JS, Marritt, SJ, Gareta, EG, Cammack, R, McKie, AT

Biochim Biophys Acta 2008
16510471 Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells

Turi, JL, Wang, X, McKie, AT, Nozik-Grayck, E, Mamo, LB, Crissman, K, Piantadosi, CA, Ghio, AJ

Am J Physiol Lung Cell Mol Physiol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, oxidizing metal ions of CYBRD1:Heme [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created