Reactome | Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein

Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein

Stable Identifier

R-HSA-914010

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). They catalyse the addition of N-acetylglucosamine to the T antigen to form the Core 3 glycoprotein (Togayachi et al, 2006). Thie reaction occurs in the Golgi.

Literature References

PubMed ID	Title	Journal	Year
17113861	Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif Narimatsu, H, Sato, T, Togayachi, A	Methods Enzymol	2006
15560372	Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase Gu, S, Li, Y, Yin, G, Zhang, J, Xie, Y, Li, J, Zheng, H, Ye, X, Mao, Y, Zou, X, Xu, J, Ji, C, Wu, M	Mol Biol Rep	2004
11283017	Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids Mio, H, Sasaki, K, Irimura, T, Akashima, T, Iwasaki, H, Kudo, T, Ookubo, R, Narimatsu, H, Togayachi, A, Inokuchi, J, Natsume, A, Nishihara, S	J Biol Chem	2001
15486459	Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family Shan, Y, Wu, S, Huang, C, Teng, S, Zhou, J, Yu, L	Glycoconj J	2004
11042166	Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family Shiraishi, N, Sasaki, K, Imai, N, Yamada, Y, Akashima, T, Nakagawa, S, Sekine, S, Koizumi, S, Narimatsu, H, Endo, T, Togayachi, A, Natsume, A	J Biol Chem	2001
9417100	Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains Streiff, MB, Katopodis, AG, Kolbinger, F	J Biol Chem	1998
15620693	A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer Iwai, T, Kudo, T, Gotoh, M, Sakai, T, Narimatsu, H, Inaba, N, Shoda, J, Togayachi, A, Tanaka, N, Okubo, R, Hiruma, T, Sato, T, Ishida, H	FEBS Lett	2005
11821425	Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans Iwai, T, Kudo, T, Iwasaki, H, Nakanishi, H, Gotoh, M, Ishizuka, Y, Zhang, Y, Narimatsu, H, Inaba, N, Togayachi, A, Naundorf, A	J Biol Chem	2002