Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein

Stable Identifier
Reaction [transition]
Homo sapiens
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The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). They catalyse the addition of N-acetylglucosamine to the T antigen to form the Core 3 glycoprotein (Togayachi et al, 2006). Thie reaction occurs in the Golgi.

Literature References
PubMed ID Title Journal Year
17113861 Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif

Narimatsu, H, Sato, T, Togayachi, A

Methods Enzymol 2006
15560372 Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase

Gu, S, Li, Y, Yin, G, Zhang, J, Xie, Y, Li, J, Zheng, H, Ye, X, Mao, Y, Zou, X, Xu, J, Ji, C, Wu, M

Mol Biol Rep 2004
11283017 Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids

Mio, H, Sasaki, K, Irimura, T, Akashima, T, Iwasaki, H, Kudo, T, Ookubo, R, Narimatsu, H, Togayachi, A, Inokuchi, J, Natsume, A, Nishihara, S

J Biol Chem 2001
15486459 Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family

Shan, Y, Wu, S, Huang, C, Teng, S, Zhou, J, Yu, L

Glycoconj J 2004
11042166 Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family

Shiraishi, N, Sasaki, K, Imai, N, Yamada, Y, Akashima, T, Nakagawa, S, Sekine, S, Koizumi, S, Narimatsu, H, Endo, T, Togayachi, A, Natsume, A

J Biol Chem 2001
9417100 Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains

Streiff, MB, Katopodis, AG, Kolbinger, F

J Biol Chem 1998
15620693 A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer

Iwai, T, Kudo, T, Gotoh, M, Sakai, T, Narimatsu, H, Inaba, N, Shoda, J, Togayachi, A, Tanaka, N, Okubo, R, Hiruma, T, Sato, T, Ishida, H

FEBS Lett 2005
11821425 Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans

Iwai, T, Kudo, T, Iwasaki, H, Nakanishi, H, Gotoh, M, Ishizuka, Y, Zhang, Y, Narimatsu, H, Inaba, N, Togayachi, A, Naundorf, A

J Biol Chem 2002
Catalyst Activity

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity of B3GNTs [Golgi membrane]

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