Reactome | ENTPD1 [plasma membrane]

ENTPD1 [plasma membrane]

Stable Identifier

R-HSA-913566

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ectonucleoside triphosphate diphosphohydrolase 1, Ecto-ADPase 1, ENTP1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Cell recruitment (pro-inflammatory response) (Homo sapiens)
      - Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)
        
        NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
        
        NTPDase1 [plasma membrane] (Homo sapiens)
        
        ENTPD1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49961 ENTPD1

Gene Names

ENTPD1, CD39

Chain

chain:1-510

Reference Genes

BioGPS Gene:953 ENTPD1

COSMIC (genes):ENTPD1 ENTPD1

CTD Gene:953 ENTPD1

dbSNP Gene:953 ENTPD1

ENSEMBL:ENSG00000138185.20 ENTPD1

HGNC:3363 ENTPD1

KEGG Gene (Homo sapiens):953 ENTPD1

Monarch:953 ENTPD1

NCBI Gene:953 ENTPD1

OMIM:601752 ENTPD1

UCSC:P49961 ENTPD1

Reference Transcript

Other Identifiers

0006200332

0104920138

11724006_a_at

11724007_s_at

11724008_a_at

11749188_a_at

16707791

207691_PM_x_at

207691_x_at

209473_PM_at

209473_at

209474_PM_s_at

209474_s_at

228585_PM_at

228585_at

3259257

3259261

3259262

3259279

3259280

3259285

3259286

3259288

3259289

3259293

3259294

3259300

3259301

3259304

3259306

3259307

3259308

3259309

3259310

3259311

3259312

3259313

3259314

3259315

3259316

3259317

3259318

32826_at

47051_at

7929511

953

A_23_P24260

A_24_P335025

A_33_P3218975

A_33_P3218980

GE79307

GE88065

GO:0000166

GO:0004382

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005886

GO:0005887

GO:0007155

GO:0007596

GO:0009134

GO:0016020

GO:0016021

GO:0016787

GO:0017110

GO:0042060

GO:0043226

GO:0045134

GO:0055086

GO:0070062

HMNXSV003016795

HMNXSV003033531

Hs.205353.1.S2_3p_at

Hs.7514.0.A1_3p_at

ILMN_1773125

PH_hs_0025943

PH_hs_0041105

S73813_at

g1842119_3p_a_at

Participates

as a component of

NTPDase1 [plasma membrane] (Homo sapiens)

Inferred To

gdp1 [plasma membrane] (Schizosaccharomyces pombe)

Homologues of ENTPD1 [plasma membrane] (Plasmodium falciparum)

ENTPD1 [plasma membrane] (Bos taurus)

ENTPD1 [plasma membrane] (Canis familiaris)

ENTPD1 [plasma membrane] (Danio rerio)

ENTPD1 [plasma membrane] (Gallus gallus)

ENTPD1 [plasma membrane] (Plasmodium falciparum)

ENTPD1 [plasma membrane] (Sus scrofa)

ENTPD1 [plasma membrane] (Xenopus tropicalis)

Entpd1 [plasma membrane] (Mus musculus)

Entpd1 [plasma membrane] (Rattus norvegicus)

GDA1 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001157650.1, NP_001157655.1, XP_016872448.1, NP_001157654.1, XP_011538679.1, NP_001157653.1, NP_001767.3, NP_001307845.1, NP_001091645.1, XP_011538673.1, NP_001299583.1

Guide to Pharmacology - Targets

2888

OpenTargets

ENSG00000138185

ZINC - Substances

ENTP1_HUMAN

ZINC target

P49961

PRO

P49961

GeneCards

P49961

HPA

ENSG00000138185-ENTPD1

Ensembl

ENSP00000390955, ENSG00000138185, ENSP00000442968, ENST00000371205, ENST00000453258, ENSP00000360250, ENSP00000360248, ENST00000371207, ENST00000543964

Pharos - Targets

P49961

Orphanet

22900

ZINC - Predictions - Purchasable

ENTP1_HUMAN

HMDB Protein

HMDBP00084

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.581	5