Reactome | GM-CSF receptor alpha:GM-CSF binds Bc

GM-CSF receptor alpha:GM-CSF binds Bc

Stable Identifier

R-HSA-913371

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The alpha subunit of the GM-CSF receptor binds GM-CSF with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of GM-CSF with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
1833064	Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors Kitamura, T, Sato, N, Arai, K, Miyajima, A	Cell	1991
18692472	The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation Hansen, G, Hercus, TR, McClure, BJ, Stomski, FC, Dottore, M, Powell, J, Ramshaw, H, Woodcock, JM, Xu, Y, Guthridge, M, McKinstry, WJ, Lopez, AF, Parker, MW	Cell	2008
1702217	Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor Hayashida, K, Kitamura, T, Gorman, DM, Arai, K, Yokota, T, Miyajima, A	Proc Natl Acad Sci U S A	1990