GM-CSF receptor alpha:GM-CSF binds Bc

Stable Identifier
R-HSA-913371
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The alpha subunit of the GM-CSF receptor binds GM-CSF with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of GM-CSF with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).

Literature References
PubMed ID Title Journal Year
1833064 Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

Arai, K, Miyajima, A, Sato, N, Kitamura, T

Cell 1991
18692472 The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

Guthridge, M, Stomski, FC, Ramshaw, H, McClure, BJ, Lopez, AF, Powell, J, Dottore, M, Xu, Y, Hercus, TR, Woodcock, JM, McKinstry, WJ, Parker, MW, Hansen, G

Cell 2008
1702217 Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

Arai, K, Hayashida, K, Miyajima, A, Yokota, T, Gorman, DM, Kitamura, T

Proc Natl Acad Sci U S A 1990
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!