GM-CSF receptor alpha subunit binds GM-CSF

Stable Identifier
R-HSA-913360
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GM-CSF receptor alpha subunit binds GM-CSF
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The GM-CSF receptor alpha subunit has a single transmembrane domain, a glycosylated extracellular domain and a short (54 amino acids) cytoplasmic tail, containing no tyrosine kinase domain (Gearing et al. 1989). It binds GM-CSF with a relatively low affinity, and is not capable of signaling. The cytoplasmic domain of the alpha chain appears to be critical for GM-CSF signaling (Matsuguchi et al. 1997).
Literature References
PubMed ID Title Journal Year
2555171 Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor

Nicola, NA, Gearing, DP, Gough, NM, King, JA

EMBO J 1989
Participants
Input
Output
Participates
as an event of
Orthologous Events
GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)
GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Hercus, TR  (2010-09-06)
Lopez, AF  (2010-09-06)
Created
Jupe, S  (2010-07-14)
Cite Us!