CBL binds B-cell linker protein

Stable Identifier
R-HSA-912724
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CBL binds B-cell linker protein
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Cbl binds B-cell linker protein, a molecular scaffold bridging Syk to downstream signaling pathways by recruiting signaling molecules, such as Btk, phospholipase C gamma 2, Vav, and Grb2 to the cell membrane to form a signalosome complex. Cbl is believed to negatively regulate signaling from this complex. Consistent with this, Cbl inactivation reverses a number of critical defects in early B cell differentiation seen in BLNK-deficient mice (Song et al. 2007).
Literature References
PubMed ID Title Journal Year
17202354 Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway

Chiang, YJ, Hodes, RJ, Song, H, Zhang, J, Siraganian, RP

J Immunol 2007
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Cbl binds B-cell linker protein (Gallus gallus)
Authored
Ray, KP  (2010-05-17)
Reviewed
Hercus, TR  (2010-09-06)
Lopez, AF  (2010-09-06)
Created
Jupe, S  (2010-07-13)
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