CBL ubiquitinates PI3K

Stable Identifier
R-HSA-912627
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Cbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl-B targets PI3K for ubiquitination and degradation in T cells (Fang et al. 2000). Similarly, Cbl activation by tyrosine phosphorylation increases PI3K ubiquitination and proteasomal degradation (Dufour et al. 2008).

Literature References
PubMed ID Title Journal Year
18374639 FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival

Dufour, C, Guenou, H, Kaabeche, K, Bouvard, D, Sanjay, A, Marie, PJ

Bone 2008
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Orthologous Events
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