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ATP6V1E2 [cytosol]
Stable Identifier
R-HSA-912579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B exchanges GDP for GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
RRAGC,D exchanges GTP for GDP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
RRAGC,D hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
mTORC1 binds RHEB:GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
V-ATPase [phagocytic vesicle membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
Endosome acidification (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1E [cytosol] (Homo sapiens)
ATP6V1E2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96A05 ATP6V1E2
Gene Names
ATP6V1E2, ATP6E1, ATP6EL2, ATP6V1EL2
Chain
chain:1-226
Reference Genes
BioGPS Gene:90423 ATP6V1E2
COSMIC (genes):ATP6V1E2 ATP6V1E2
CTD Gene:90423 ATP6V1E2
dbSNP Gene:90423 ATP6V1E2
ENSEMBL:ENSG00000250565 ATP6V1E2
HGNC:18125 ATP6V1E2
KEGG Gene (Homo sapiens):90423 ATP6V1E2
Monarch:90423 ATP6V1E2
NCBI Gene:90423 ATP6V1E2
OMIM:617385 ATP6V1E2
UCSC:Q96A05 ATP6V1E2
Reference Transcript
RefSeq:XM_011533149.2 ATP6V1E2
RefSeq:XM_011533148.2 ATP6V1E2
RefSeq:XM_017005226.1 ATP6V1E2
RefSeq:XM_005264634.2 ATP6V1E2
RefSeq:XM_017005225.1 ATP6V1E2
RefSeq:XM_005264633.2 ATP6V1E2
RefSeq:XM_011533153.2 ATP6V1E2
RefSeq:NM_001318063.1 ATP6V1E2
RefSeq:XM_011533152.2 ATP6V1E2
RefSeq:XM_011533151.2 ATP6V1E2
RefSeq:XM_011533150.2 ATP6V1E2
Other Identifiers
0002230736
11728554_at
11728555_s_at
1552286_PM_at
1552286_at
1557372_PM_at
1557372_at
2551652
2551653
2551654
2551656
2551664
2551665
2551667
2551669
2551673
8051989
87834_at
89901_s_at
90423
A_23_P143047
GE521856
GO:0001669
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006810
GO:0006811
GO:0006914
GO:0008150
GO:0009056
GO:0016241
GO:0022857
GO:0031410
GO:0032991
GO:0033178
GO:0043226
GO:0046961
GO:0055085
GO:0140657
GO:1902600
HMNXSV003031164
Hs2.336620.1.S1_3p_at
Hs2.405881.1.S1_3p_at
ILMN_1810235
PH_hs_0025634
TC02004216.hg
Participates
as a member of
ATP6V1E [cytosol] (Homo sapiens)
Inferred To
Atp6v1e2 [cytosol]
(Mus musculus)
Atp6v1e2 [cytosol]
(Rattus norvegicus)
VMA4 [cytosol]
(Saccharomyces cerevisiae)
ATP6V1E1 [cytosol]
(Gallus gallus)
Homologues of ATP6V1E2 [cytosol]
(Danio rerio)
atp6v1e1a [cytosol]
(Danio rerio)
vma4 [cytosol]
(Schizosaccharomyces pombe)
ATP6V1E2 [cytosol]
(Bos taurus)
ATP6V1E2 [cytosol]
(Plasmodium falciparum)
ATP6V1E2 [cytosol]
(Sus scrofa)
atp6v1e1 [cytosol]
(Xenopus tropicalis)
vatE [cytosol]
(Dictyostelium discoideum)
atp6v1e1b [cytosol]
(Danio rerio)
vha-8 [cytosol]
(Caenorhabditis elegans)
Vha26 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011531454.1
,
XP_016860714.1
,
XP_005264691.1
,
XP_016860715.1
,
NP_001304992.1
,
XP_011531452.1
,
XP_011531451.1
,
XP_011531453.1
,
XP_011531450.1
,
XP_011531455.1
,
XP_005264690.1
Guide to Pharmacology - Targets
817
OpenTargets
ENSG00000250565
HPA
ENSG00000250565-ATP6V1E2
GeneCards
Q96A05
Ensembl
ENSG00000250565
,
ENST00000522587
,
ENSP00000304891
,
ENST00000306448
,
ENSP00000428141
PRO
Q96A05
Pharos - Targets
Q96A05
HMDB Protein
HMDBP04033
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