ATR Kinase is recruited to unsynapsed regions

Stable Identifier
R-HSA-912450
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ATR Kinase is recruited to unsynapsed regions
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Unsynapsed regions of chromosomes accumulate BRCA1, the kinase ATR, and the phosphorylated histone gammaH2AX. In mouse the recruitment of ATR depends on BRCA1.

Literature References
PubMed ID Title Journal Year
19146767 ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes

Garcia Caldés, M, Robles, P, Scherthan, H, Garcia-Cruz, R, Roig, I

Reprod Biomed Online 2009
Participants
Input
Output
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as an event of
Inferred From
Recruitment of Atr Kinase to Unsynapsed Regions (Mus musculus)
Authored
May, B  (2010-07-19)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2010-07-09)
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