ATR Kinase is recruited to unsynapsed regions

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R-HSA-912450
Type
Reaction [binding]
Species
Homo sapiens
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Unsynapsed regions of chromosomes accumulate BRCA1, the kinase ATR, and the phosphorylated histone gammaH2AX. In mouse the recruitment of ATR depends on BRCA1.

Literature References
PubMed ID Title Journal Year
19146767 ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes

Garcia-Cruz, R, Roig, I, Robles, P, Scherthan, H, Garcia Cald├ęs, M

Reprod Biomed Online 2009
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