Formation of p-STAT1 homodimer

Stable Identifier
R-HSA-909718
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Formation of p-STAT1 homodimer
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Under certain conditions type I IFNs, IFNA/B are able to activate genes through a second STAT-based signaling cascade enabling the formation of p-STAT1:p-STAT1 homodimers called IFNA-activated-factor (AAF).
Literature References
PubMed ID Title Journal Year
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Shuai, K, Horvath, CM, Huang, LH, Qureshi, SA, Cowburn, D, Darnell JE, Jr

Cell 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane]

Physical Entity
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Formation of p-STAT1 homodimer (Bos taurus)
Formation of p-STAT1 homodimer (Canis familiaris)
Formation of p-STAT1 homodimer (Danio rerio)
Formation of p-STAT1 homodimer (Gallus gallus)
Formation of p-STAT1 homodimer (Mus musculus)
Formation of p-STAT1 homodimer (Rattus norvegicus)
Formation of p-STAT1 homodimer (Sus scrofa)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-07)
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