NR1H2,3 binds the APOC4 gene

Stable Identifier
Reaction [binding]
Homo sapiens
LXR binds the APOC4 gene
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Apolipoprotein C4 (APOC4) is present in the APOE, APOC1, APOC4 and APOC2-gene cluster which is induced by natural and synthetic ligands of liver X receptors (LXRα, NR1H3 and LXRβ, NR1H2) in both human and mouse macrophages (Mak PA et al. 2002). The induction of all four mRNAs was greatly attenuated in macrophages derived from LXR α/β-/- mice (Mak PA et al. 2002). Cell reporter assays suggest that the LXR response elements (LXRE) in the multienhancer regions ME.1 and ME.2, which confer tissue-specific expression in macrophages and adipocytes (Shih SJ et al. 2000), are necessary for the expression of this gene cluster (Mak PA et al. 2002). These secreted apolipoproteins regulate lipid transport and catabolism.

Literature References
PubMed ID Title Journal Year
12032151 Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

Mak, PA, Laffitte, BA, Desrumaux, C, Joseph, SB, Curtiss, LK, Mangelsdorf, DJ, Tontonoz, P, Edwards, PA

J. Biol. Chem. 2002
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