PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)

Stable Identifier
R-HSA-9033238
Type
Reaction
Species
Homo sapiens
Compartment
peroxisomal membrane
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PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
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PEX5L bound to PEX7:Cargo interacts with the peroxisomal membrane complex PEX13:PEX14:PEX2:PEX10:PEX12 (the Docking-Translocation Complex) thus bringing PEX7 and its cargo to dock at the peroxisomal membrane (Gould et al. 1996, Fransen et al. 1998, Will et al. 1999, Dodt et al. 2001, Rodrigues et al. 2014, Rodrigues et al. 2015, also inferred from hamster and rat homologues).

Literature References
PubMed ID Title Journal Year
9653144 Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import

Fransen, M, Terlecky, SR, Subramani, S

Proc. Natl. Acad. Sci. U.S.A. 1998
8858165 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor

Gould, SJ, Kalish, JE, Morrell, JC, Bjorkman, J, Urquhart, AJ, Crane, DI

J. Cell Biol. 1996
24865970 A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway

Rodrigues, TA, Alencastre, IS, Francisco, T, Brites, P, Fransen, M, Grou, CP, Azevedo, JE

Mol. Cell. Biol. 2014
26138649 Revisiting the intraperoxisomal pathway of mammalian PEX7

Rodrigues, TA, Grou, CP, Azevedo, JE

Sci Rep 2015
10022913 Identification and characterization of the human orthologue of yeast Pex14p

Will, GK, Soukupova, M, Hong, X, Erdmann, KS, Kiel, JA, Dodt, G, Kunau, WH, Erdmann, R

Mol. Cell. Biol. 1999
11546814 Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p

Dodt, G, Warren, D, Becker, E, Rehling, P, Gould, SJ

J. Biol. Chem. 2001
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Pex14 binds PEX5L (in PEX5L:PEX7:Acaa1a) (Cricetulus griseus)
Authored
May, B  (2017-12-19)
Reviewed
Fransen, M  (2018-02-13)
Van Veldhoven, PP  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-20)