PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PEX5S or PEX5L bound to cargo proteins containing PTS1 interacts with the Docking and Translocation Module (PEX13:PEX14:PEX2:PEX10:PEX12) (Gould et al. 1996, Fransen et al. 1998, Will et al. 1999, Neufeld et al. 2009, Shiozawa et al. 2009, Freitas et al. 2011, Francisco et al. 2013, Neufeld et al. 2014, Dias et al. 2017).

Literature References
PubMed ID Title Journal Year
19197237 Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19

Schliebs, W, Filipp, FV, Wilmanns, M, Schüller, N, Simon, B, Kooshapur, H, Sattler, M, Madl, T, Neufeld, C, Erdmann, R, Neuhaus, A, David, C

EMBO J. 2009
8858165 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor

Bjorkman, J, Morrell, JC, Kalish, JE, Gould, SJ, Urquhart, AJ, Crane, DI

J. Cell Biol. 1996
9653144 Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import

Subramani, S, Terlecky, SR, Fransen, M

Proc. Natl. Acad. Sci. U.S.A. 1998
24235149 A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes

Schliebs, W, Jung, M, Saidowsky, J, Lazam, A, Wolf, J, Hambruch, E, Kooshapur, H, Sattler, M, Meyer, NH, Madl, T, Erdmann, R, Neuhaus, A

J. Biol. Chem. 2014
21976670 PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14

Sá-Miranda, C, Rodrigues, TA, Grou, CP, Freitas, MO, Carvalho, AF, Alencastre, IS, Azevedo, JE, Pinto, MP, Fransen, M, Francisco, T

J. Biol. Chem. 2011
23963456 A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway

Sá-Miranda, C, Rodrigues, TA, Grou, CP, Freitas, MO, Carvalho, AF, Azevedo, JE, Pinto, MP, Francisco, T

J. Biol. Chem. 2013
28765278 The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo

Barros-Barbosa, A, Pedrosa, AG, Rodrigues, TA, Dias, AF, Azevedo, JE, Francisco, T

J. Biol. Chem. 2017
10022913 Identification and characterization of the human orthologue of yeast Pex14p

Kiel, JA, Kunau, WH, Will, GK, Erdmann, KS, Hong, X, Soukupova, M, Erdmann, R, Dodt, G

Mol. Cell. Biol. 1999
19584060 Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering

Svergun, DI, Konarev, PV, Wilmanns, M, Shiozawa, K, Neufeld, C

J. Biol. Chem. 2009
Orthologous Events
Cite Us!