Reactome | PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)

PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)

Stable Identifier

R-HSA-9033236

Type

Reaction [binding]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

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PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)

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PEX5S or PEX5L bound to cargo proteins containing PTS1 interacts with the Docking and Translocation Module (PEX13:PEX14:PEX2:PEX10:PEX12) (Gould et al. 1996, Fransen et al. 1998, Will et al. 1999, Neufeld et al. 2009, Shiozawa et al. 2009, Freitas et al. 2011, Francisco et al. 2013, Neufeld et al. 2014, Dias et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
19197237	Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19 Schliebs, W, Filipp, FV, Wilmanns, M, Schüller, N, Simon, B, Kooshapur, H, Sattler, M, Madl, T, Neufeld, C, Erdmann, R, Neuhaus, A, David, C	EMBO J.	2009
8858165	Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor Bjorkman, J, Morrell, JC, Kalish, JE, Gould, SJ, Urquhart, AJ, Crane, DI	J. Cell Biol.	1996
9653144	Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import Subramani, S, Terlecky, SR, Fransen, M	Proc. Natl. Acad. Sci. U.S.A.	1998
24235149	A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes Schliebs, W, Jung, M, Saidowsky, J, Lazam, A, Wolf, J, Hambruch, E, Kooshapur, H, Sattler, M, Meyer, NH, Madl, T, Erdmann, R, Neuhaus, A	J. Biol. Chem.	2014
21976670	PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14 Sá-Miranda, C, Rodrigues, TA, Grou, CP, Freitas, MO, Carvalho, AF, Alencastre, IS, Azevedo, JE, Pinto, MP, Fransen, M, Francisco, T	J. Biol. Chem.	2011
23963456	A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway Sá-Miranda, C, Rodrigues, TA, Grou, CP, Freitas, MO, Carvalho, AF, Azevedo, JE, Pinto, MP, Francisco, T	J. Biol. Chem.	2013
28765278	The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo Barros-Barbosa, A, Pedrosa, AG, Rodrigues, TA, Dias, AF, Azevedo, JE, Francisco, T	J. Biol. Chem.	2017
10022913	Identification and characterization of the human orthologue of yeast Pex14p Kiel, JA, Kunau, WH, Will, GK, Erdmann, KS, Hong, X, Soukupova, M, Erdmann, R, Dodt, G	Mol. Cell. Biol.	1999
19584060	Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering Svergun, DI, Konarev, PV, Wilmanns, M, Shiozawa, K, Neufeld, C	J. Biol. Chem.	2009