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PEX6 [cytosol]
Stable Identifier
R-HSA-9033104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peroxisome assembly factor 2, PEX6_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
PEX6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13608 PEX6
Gene Names
PEX6, PXAAA1
Chain
chain:1-980
Reference Genes
BioGPS Gene:5190 PEX6
COSMIC (genes):PEX6 PEX6
CTD Gene:5190 PEX6
dbSNP Gene:5190 PEX6
ENSEMBL:ENSG00000124587 PEX6
ENSEMBL_homo_sapiens_GENE:ENSG00000124587.14 PEX6
HGNC:8859 PEX6
KEGG Gene (Homo sapiens):5190 PEX6
Monarch:5190 PEX6
NCBI Gene:5190 PEX6
OMIM:601498 PEX6
UCSC:Q13608 PEX6
Reference Transcript
RefSeq:NM_001316313.1 PEX6
RefSeq:NM_000287.3 PEX6
Other Identifiers
11720549_a_at
11749004_a_at
17019260
204545_PM_at
204545_at
2954282
2954283
2954284
2954285
2954286
2954288
2954289
2954290
2954292
2954293
2954294
2954296
2954297
2954299
2954300
2954301
2954305
2954307
2954308
2954309
2954312
2954313
2954316
2954317
2954318
2954319
2954320
2954321
320_PM_at
320_at
5190
8126452
91517_at
91658_at
A_23_P42144
A_33_P3265016
D83703_at
GE57336
GO:0000166
GO:0001750
GO:0003824
GO:0005215
GO:0005515
GO:0005524
GO:0005737
GO:0005777
GO:0005778
GO:0005829
GO:0005929
GO:0006625
GO:0006886
GO:0007031
GO:0016020
GO:0016558
GO:0016561
GO:0016562
GO:0016787
GO:0016887
GO:0042995
GO:0043226
GO:0043335
GO:0044877
GO:0050821
GO:0055085
GO:0097733
GO:0140036
GO:0140318
GO:0140657
HMNXSV003009140
ILMN_1683279
PH_hs_0015553
TC06001740.hg
g4505728_3p_s_at
Participates
as a component of
PEX1:PEX6:PEX26 [peroxisomal membrane] (Homo sapiens)
Inferred To
PEX6 [cytosol]
(Bos taurus)
PEX6 [cytosol]
(Canis familiaris)
PEX6 [cytosol]
(Dictyostelium discoideum)
PEX6 [cytosol]
(Gallus gallus)
PEX6 [cytosol]
(Mus musculus)
PEX6 [cytosol]
(Rattus norvegicus)
PEX6 [cytosol]
(Saccharomyces cerevisiae)
PEX6 [cytosol]
(Schizosaccharomyces pombe)
PEX6 [cytosol]
(Sus scrofa)
prx-6 [cytosol]
(Caenorhabditis elegans)
Pex6 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000278.3
,
NP_001303242.1
OpenTargets
ENSG00000124587
GeneCards
Q13608
HPA
ENSG00000124587-PEX6
Ensembl
ENST00000244546
,
ENSP00000303511
,
ENSG00000124587
,
ENSP00000244546
,
ENST00000304611
PRO
Q13608
Pharos - Targets
Q13608
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17980 PSMC3
5
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [cytosol]
(R-HSA-68774)
0.527
3
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