NTRK2 phosphorylates FRS3

Stable Identifier
R-HSA-9032426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated NTRK2 (TRKB) receptor phosphorylates FRS3 (also known as FRS2beta or STN2). Downstream of NTRK1 (TRKA)-mediated recruitment and phosphorylation, phosphorylated FRS3 binds to GRB2, SHP2 (PTPN11) and CKS proteins (CKS1, also known as CKS1B, and CKS2). FRS3 binding to GRB2, PTPN11 and CKSs has not been examined in the context of NTRK2 signaling (Dixon et al. 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created