NTRK2-phosphorylated FRS2 binds GRB2

Stable Identifier
R-HSA-9032073
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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NTRK2-phosphorylated FRS2 binds GRB2
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BDNF treatment induces formation of a complex between FRS2 and GRB2 and leads to activation of RAS signaling. It is assumed that SOS1 is in complex with GRB2, although this has not been experimentally verified (Easton et al. 1999).

Literature References
PubMed ID Title Journal Year
10196222 Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2

Middlemas, DS, Zhu, X, Moody, NM, Easton, JB

J. Biol. Chem. 1999
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Orthologous Events
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NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)
NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)
NTRK2-phosphorylated FRS2 binds GRB2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-05)
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