Reactome | ALOX5 oxidises EPA to 5-HEPE

ALOX5 oxidises EPA to 5-HEPE

Stable Identifier

R-HSA-9027628

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of eicosapentaenoic acid (EPA) to 5-hydroxy-eicosapentaenoic acid (5-HEPE) (Cipollina et al. 2014, Powell et al. 1995). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 5-oxo-EPA and its hydroxy precursor 5-HEPE, demonstrating that ALOX5 mediates the first step in 5-oxo-EPA biosynthesis (Cipollina et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24736647	Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ	PLoS ONE	2014
8847485	Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils Powell, WS, Gravel, S, Gravelle, F	J. Lipid Res.	1995