ALOX5 oxidises EPA to 5-HEPE

Stable Identifier
R-HSA-9027628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of eicosapentaenoic acid (EPA) to 5-hydroxy-eicosapentaenoic acid (5-HEPE) (Cipollina et al. 2014, Powell et al. 1995). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 5-oxo-EPA and its hydroxy precursor 5-HEPE, demonstrating that ALOX5 mediates the first step in 5-oxo-EPA biosynthesis (Cipollina et al. 2014).

Literature References
PubMed ID Title Journal Year
8847485 Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils

Powell, WS, Gravel, S, Gravelle, F

J. Lipid Res. 1995
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ

PLoS ONE 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]
Physical Entity
Activity
Orthologous Events
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