ALOX5 oxidises DHA to 7-HDHA

Stable Identifier
R-HSA-9027624
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALOX5 oxidises DHA to 7-HDHA
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In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of docosahexaenoic acid (DHA) to 7-hydroxy-docosahexaenoic acid (7-HDHA) (Cipollina et al. 2014). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 7-oxo-DHA and its hydroxy precursor 7-HDHA, demonstrating that ALOX5 mediates the first step in 5-oxo-DHA biosynthesis (Cipollina et al. 2014).
Literature References
PubMed ID Title Journal Year
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ

PLoS ONE 2014
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Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]

Physical Entity
ALOX5 [cytosol] (Homo sapiens)
Activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701)
Orthologous Events
ALOX5 oxidises DHA to 7-HDHA (Bos taurus)
ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)
ALOX5 oxidises DHA to 7-HDHA (Danio rerio)
ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)
ALOX5 oxidises DHA to 7-HDHA (Gallus gallus)
ALOX5 oxidises DHA to 7-HDHA (Mus musculus)
ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)
ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)
ALOX5 oxidises DHA to 7-HDHA (Xenopus tropicalis)
Authored
Jassal, B  (2017-11-03)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-11-03)
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