Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3

Stable Identifier
R-HSA-9027600
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In activated macrophages, an unknown dehdyrogenase abstracts hydrogen from 17-hydroxy-docosapentaenoic acid (17-HDPAn-3) to form the electrophilic oxo (EFOX) derivative 17-oxo-DPAn-3 (Groeger et al. 2010). Potential candidates are cellular dehydrogenases such as 3α-hydroxysteroid dehydrogenases (3α-HSDs), which can convert 13- and 17-HDHA into corresponding EFOXs in the presence of NAD(P)+ in vitro(supplementary data, Groeger et al. 2010) or 5- and 15-hydroxyeicosanoid dehydrogenases (5- and 15-HEDH, Wendell et al. 2015), which convert LOX products to 5-and 15-oxoETE (Erlemann et al. 2007). 17-oxo-DPAn-3 can act as a peroxisome proliferator-activated receptor-γ (PPARγ) agonist and inhibit pro-inflammatory cytokine and nitric oxide production, confirming its anti-inflammatory actions (Groeger et al. 2010).

Literature References
PubMed ID Title Journal Year
20436486 Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

Groeger, AL, Cipollina, C, Cole, MP, Woodcock, SR, Bonacci, G, Rudolph, TK, Rudolph, V, Freeman, BA, Schopfer, FJ

Nat. Chem. Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldo-keto reductase (NADP) activity of Dehydrogenase [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created
Cite Us!