Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3

Stable Identifier
R-HSA-9027598
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3
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In activated macrophages, an unknown dehdyrogenase abstracts hydrogen from 13-hydroxy-docosapentaenoic acid (13(R)-HDPAn-3) to form the electrophilic oxo (EFOX)derivative 13-oxo-DPAn-3 (Groeger et al. 2010). Potential candidates are cellular dehydrogenases such as 3α-hydroxysteroid dehydrogenases (3α-HSDs), which can convert 13- and 17-HDHA into corresponding EFOXs in the presence of NAD(P)+ in vitro (supplementary data, Groeger et al. 2010) or 5- and 15-hydroxyeicosanoid dehydrogenases (5- and 15-HEDH), which convert LOX products to 5-and 15-oxoETE (Erlemann et al. 2007). EFOXs can act as peroxisome proliferator-activated receptor-γ (PPARγ) agonists and inhibit pro-inflammatory cytokine and nitric oxide production, confirming their anti-inflammatory actions (Groeger et al. 2010).
Literature References
PubMed ID Title Journal Year
20436486 Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

Cipollina, C, Schopfer, FJ, Cole, MP, Rudolph, V, Freeman, BA, Groeger, AL, Rudolph, TK, Bonacci, G, Woodcock, SR

Nat. Chem. Biol. 2010
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Catalyst Activity

aldo-keto reductase (NADPH) activity of Dehydrogenase [cytosol]

Physical Entity
Dehydrogenase [cytosol] (Homo sapiens)
Activity
aldo-keto reductase (NADPH) activity (GO:0004033)
Authored
Jassal, B  (2017-11-03)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-11-03)
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