JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1

Stable Identifier
R-HSA-9027273
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
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Phosphorylated JAK2 in a complex with EPOR and GAB1 phosphorylates GAB1 on unknown tyrosine residues (Lecoq-Lafon et al. 1999, Wickrema et al. 1999, Bouscary et al. 2003, Fukumoto et al. 2009). Phosphorylated GAB1 serves as a scaffold for binding downstream signaling molecules including phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Bouscary et al. 2003).
Literature References
PubMed ID Title Journal Year
10194437 Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase

Lecoq-Lafon, C, Verdier, F, Fichelson, S, Chrétien, S, Gisselbrecht, S, Lacombe, C, Mayeux, P

Blood 1999
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chrétien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
10455108 Engagement of Gab1 and Gab2 in erythropoietin signaling

Wickrema, A, Uddin, S, Sharma, A, Chen, F, Alsayed, Y, Ahmad, S, Sawyer, ST, Krystal, G, Yi, T, Nishada, K, Hibi, M, Hirano, T, Platanias, LC

J Biol Chem 1999
19665053 Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells

Fukumoto, T, Kubota, Y, Kitanaka, A, Yamaoka, G, Ohara-Waki, F, Imataki, O, Ohnishi, H, Ishida, T, Tanaka, T

Cell. Signal. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane]

Physical Entity
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Xenopus tropicalis)
Authored
May, B  (2017-10-29)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-29)
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