JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated JAK2 in a complex with EPOR and GAB1 phosphorylates GAB1 on unknown tyrosine residues (Lecoq-Lafon et al. 1999, Wickrema et al. 1999, Bouscary et al. 2003, Fukumoto et al. 2009). Phosphorylated GAB1 serves as a scaffold for binding downstream signaling molecules including phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Bouscary et al. 2003).
Literature References
PubMed ID Title Journal Year
10194437 Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase

Mayeux, P, Lecoq-Lafon, C, Lacombe, C, Verdier, F, Gisselbrecht, S, Chr├ętien, S, Fichelson, S

Blood 1999
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chr├ętien, S, Gisselbrecht, S

Blood 2003
10455108 Engagement of Gab1 and Gab2 in erythropoietin signaling

Krystal, G, Ahmad, S, Chen, F, Sharma, A, Sawyer, ST, Platanias, LC, Nishada, K, Hirano, T, Hibi, M, Yi, T, Alsayed, Y, Uddin, S, Wickrema, A

J Biol Chem 1999
19665053 Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells

Ishida, T, Tanaka, T, Yamaoka, G, Fukumoto, T, Ohara-Waki, F, Kitanaka, A, Kubota, Y, Imataki, O, Ohnishi, H

Cell. Signal. 2009
Catalyst Activity

protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane]

Orthologous Events
Cite Us!