GGT hydrolyses PCTR1 to PCTR2

Stable Identifier
R-HSA-9026912
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GGT hydrolyses PCTR1 to PCTR2
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In human macrophages, protectin conjugate in tissue regeneration 1 (PCTR1) is proposed to be hydrolysed to PCTR2 (16-cysteinylglycinyl, 17-hydroxy-docosahexaenoic acid) by the actions of a glutathione transferase (GGT). Human macrophages incubated with E. coli and a GGT inhibitor led to increased levels of PCTR1 and decreased levels of PCTR3, suggesting a role for GGT enzyme in PCTR2 and PCTR3 biosynthesis (Dalli et al. 2015).
Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
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Catalyst Activity

glutathione gamma-glutamate hydrolase activity of GGT [cytosol]

Physical Entity
GGT [cytosol] (Homo sapiens)
Activity
glutathione gamma-glutamate hydrolase (GO:0036374)
Authored
Jassal, B  (2017-10-24)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-24)
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