ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3

Stable Identifier
R-HSA-9026007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3
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In a reaction scheme that could be similar to the one for DHA-derived maresins, a lipoxygenase mediates the abstraction of hydrogen from 14(S)-hydroperoxy-docosapentaenoic acid (14(S)-Hp-DPAn-3) to form the epoxy product 13,14(S)-epoxy-docosapentaenoic acid (13,14(S)-epoxy-DPAn-3) (Dalli et al. 2013). If, as assumed, DPA metabolism follows the same path as for DHA metabolism, the lipoxygenase could be 12-lipoxygenase (ALOX12).
Literature References
PubMed ID Title Journal Year
23736886 Novel n-3 immunoresolvents: structures and actions

Serhan, CN, Colas, RA, Dalli, J

Sci Rep 2013
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Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]

Physical Entity
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Activity
arachidonate 12(S)-lipoxygenase activity (GO:0004052)
Orthologous Events
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Canis familiaris)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Sus scrofa)
Authored
Jassal, B  (2017-10-16)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-16)
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