ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3

Stable Identifier
R-HSA-9026007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In a reaction scheme that could be similar to the one for DHA-derived maresins, a lipoxygenase mediates the abstraction of hydrogen from 14(S)-hydroperoxy-docosapentaenoic acid (14(S)-Hp-DPAn-3) to form the epoxy product 13,14(S)-epoxy-docosapentaenoic acid (13,14(S)-epoxy-DPAn-3) (Dalli et al. 2013). If, as assumed, DPA metabolism follows the same path as for DHA metabolism, the lipoxygenase could be 12-lipoxygenase (ALOX12).

Literature References
PubMed ID Title Journal Year
23736886 Novel n-3 immunoresolvents: structures and actions

Dalli, J, Colas, RA, Serhan, CN

Sci Rep 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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