Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1

Stable Identifier
R-HSA-9025007
Type
Reaction [transition]
Species
Homo sapiens
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An unknown hydroperoxy reductase mediates the production of the double dioxygenation product 7(S),14(S)-hydroxy-docosa-4Z,8E,10Z,12E,16Z,19Z-hexaenoic acid (7(S),14(S)-HDHA aka 7-epi-MaR1) that proved to have less potent pro-resolving and anti-inflammatory activity than either maresin 1 (MaR1) or protectin D1 (PD1) (Serhan et al. 2009, Bannenberg & Serhan 2010).

Literature References
PubMed ID Title Journal Year
19103881 Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

Serhan, CN, Yang, R, Martinod, K, Kasuga, K, Pillai, PS, Porter, TF, Oh, SF, Spite, M

J. Exp. Med. 2009
20708099 Specialized pro-resolving lipid mediators in the inflammatory response: An update

Bannenberg, G, Serhan, CN

Biochim. Biophys. Acta 2010
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Catalyst Activity
Title
oxidoreductase activity of Hydroperoxy reductase [cytosol]
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