Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1

Stable Identifier
R-HSA-9025007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
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An unknown hydroperoxy reductase mediates the production of the double dioxygenation product 7(S),14(S)-hydroxy-docosa-4Z,8E,10Z,12E,16Z,19Z-hexaenoic acid (7(S),14(S)-HDHA aka 7-epi-MaR1) that proved to have less potent pro-resolving and anti-inflammatory activity than either maresin 1 (MaR1) or protectin D1 (PD1) (Serhan et al. 2009, Bannenberg & Serhan 2010).
Literature References
PubMed ID Title Journal Year
20708099 Specialized pro-resolving lipid mediators in the inflammatory response: An update

Serhan, CN, Bannenberg, G

Biochim. Biophys. Acta 2010
19103881 Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

Kasuga, K, Pillai, PS, Serhan, CN, Spite, M, Oh, SF, Porter, TF, Martinod, K, Yang, R

J. Exp. Med. 2009
Participants
Input
Output
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as an event of
Catalyst Activity

oxidoreductase activity of Hydroperoxy reductase [cytosol]

Physical Entity
Hydroperoxy reductase [cytosol] (Homo sapiens)
Activity
oxidoreductase activity (GO:0016491)
Authored
Jassal, B  (2017-10-11)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-11)
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