Reactome | Butyrylcholinesterase hydrolyzes acyl Ghrelin

Butyrylcholinesterase hydrolyzes acyl Ghrelin

Stable Identifier

R-HSA-9023617

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Butyrylcholinesterase hydrolyzes acyl Ghrelin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.

Literature References

PubMed ID	Title	Journal	Year
19280057	Ghrelin fluctuation, what determines its production? Yin, X, Li, Y, Zhang, W, An, W, Xu, G	Acta Biochim Biophys Sin (Shanghai)	2009
17289852	Ghrelin interacts with human plasma lipoproteins Carpentier, Y, Delporte, C, Hacquebard, M, De Vriese, C, Gregoire, F	Endocrinology	2007
18396350	Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle Soares, JB, Leite-Moreira, AF	Peptides	2008
15256494	Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites Delporte, C, Robberecht, P, Lema-Kisoka, R, De Vriese, C, Waelbroeck, M, Gregoire, F	Endocrinology	2004