Insulin secretory granule translocates across the cortical actin network

Stable Identifier
R-HSA-9023171
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Insulin secretory granule translocates across the cortical actin network
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Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Myosin Va motors along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane (inferred from mouse MIN6 cells).

Participants
Input
Output
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as an event of
Catalyst Activity

microfilament motor activity of MYO5A:MYRIP:RAB27A [cytosol]

Physical Entity
MYO5A:MYRIP:RAB27A [cytosol] (Homo sapiens)
Activity
microfilament motor activity (GO:0000146)
Inferred From
Insulin secretory granules translocate across the cortical actin network (Mus musculus)
Authored
May, B  (2017-09-25)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
May, B  (2017-09-27)
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