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PBX1 gene expression is stimulated by NOTCH3
Stable Identifier
R-HSA-9021412
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)
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PBX1 gene transcription is directly stimulated by the NOTCH3 coactivator complex (Park et al. 2008). NOTCH3 gene is amplified in high-grade ovarian serous carcinoma and NOTCH3 overexpression contributes to cancer cell growth (Park et al. 2006). Overexpression of NOTCH3 in high-grade ovarian serous carcinoma correlates with overexpression of PBX1 (Park et al. 2006, Park et al. 2008). PBX1 gene encodes a homeodomain transcription factor PBX1 which is a B cell leukemia (B-ALL) oncogene (Nourse et al. 1990, Kamps et al. 1991) and is also overexpressed in melanoma (Shiraishi et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
18974129
Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer
Park, JT
,
Wang, TL
,
Shih, IeM
Cancer Res.
2008
Participants
Input
PBX1 gene [nucleoplasm]
(Homo sapiens)
Output
PBX1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
This event is regulated
Positively by
Regulator
NOTCH3 coactivator complex:PBX1 gene [nucleoplasm]
(Homo sapiens)
Active Unit
NOTCH3 coactivator complex [nucleoplasm]
Authored
Orlic-Milacic, M (2017-09-20)
Reviewed
Haw, R (2017-10-30)
Created
Orlic-Milacic, M (2017-09-18)
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