RHOH binds effectors at the plasma membrane

Stable Identifier
R-HSA-9018758
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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RHOH plays an important role in development of T lymphocytes and binds to several kinases involved in T lymphocyte activation, including:
ZAP70 (Gu et al. 2006, Chae et al. 2010, Wang et al. 2011)
LCK (Chae et al. 2010, Wang et al. 2011)
CSK (Wang et al. 2010).

Additional RHOH interactors include:
PAK1 (Wang et al. 2010; Tajadura Ortega et al. 2018)
PAK2 (Tajadura Ortega et al. 2018)
PAK4 (Tajadura Ortega et al. 2018)
PAK5 (Wu and Frost 2006; Tajadura Ortega et al. 2018)
PAK6 (Tajadura Ortega et al. 2018)

The following RHOH interactors have only been reported in a high throughput screen by Bagci et al. 2020, and are therefore annotated as candidate RHOH effectors:
CAV1 (Bagci et al. 2020).
DBN1 (Bagci et al. 2020)
DBT (Bagci et al. 2020)
FAM91A1 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MTR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
NSFL1C (Bagci et al. 2020)
OSBPL11 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RALGAPA1 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TUBA1B (Bagci et al. 2020)
UACA (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VCP (Bagci et al. 2020)
WDR11 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
29510700 An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

Tajadura-Ortega, V, Garg, R, Allen, R, Owczarek, C, Bright, MD, Kean, S, Mohd-Noor, A, Grigoriadis, A, Elston, TC, Hahn, KM, Ridley, AJ

BMC Biol. 2018
20184954 RhoH plays distinct roles in T-cell migrations induced by different doses of SDF1 alpha

Wang, H, Zeng, X, Fan, Z, Lim, B

Cell. Signal. 2010
20851766 RhoH modulates pre-TCR and TCR signalling by regulating LCK

Wang, H, Zeng, X, Fan, Z, Lim, B

Cell. Signal. 2011
17028588 RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

Gu, Y, Chae, HD, Siefring, JE, Jasti, AC, Hildeman, DA, Williams, DA

Nat. Immunol. 2006
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
17064668 Multiple Rho proteins regulate the subcellular targeting of PAK5

Wu, X, Frost, JA

Biochem. Biophys. Res. Commun. 2006
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