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NOTCH3 coactivator complex binds DLGAP5 gene promoter
Stable Identifier
R-HSA-9018542
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH3 coactivator complex binds DLGAP5 gene promoter (Homo sapiens)
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NOTCH3 coactivator complex binds the RBPJ (CSL) response elements in the promoter of the DLGAP5 gene. Two adjacent CSL-binding motifs in the DLGAP5 promoter, which are 6 bp apart, are both necessary for NOTCH3-mediated induction of DLGAP5 transcription (Chen et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
22396495
Defining NOTCH3 target genes in ovarian cancer
Chen, X
,
Gao, M
,
Xuan, J
,
Chen, L
,
Wang, TL
,
Stoeck, A
,
Shih, IeM
,
Thiaville, MM
Cancer Res.
2012
Participants
Input
DLGAP5 gene [nucleoplasm]
(Homo sapiens)
NOTCH3 coactivator complex [nucleoplasm]
(Homo sapiens)
Output
NOTCH3 coactivator complex:DLGAP5 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
Authored
Orlic-Milacic, M (2017-09-20)
Reviewed
Haw, R (2017-10-30)
Created
Orlic-Milacic, M (2017-09-01)
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