NOTCH3 coactivator complex binds DLGAP5 gene promoter

Stable Identifier
R-HSA-9018542
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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NOTCH3 coactivator complex binds DLGAP5 gene promoter
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NOTCH3 coactivator complex binds the RBPJ (CSL) response elements in the promoter of the DLGAP5 gene. Two adjacent CSL-binding motifs in the DLGAP5 promoter, which are 6 bp apart, are both necessary for NOTCH3-mediated induction of DLGAP5 transcription (Chen et al. 2012).

Literature References
PubMed ID Title Journal Year
22396495 Defining NOTCH3 target genes in ovarian cancer

Chen, X, Gao, M, Xuan, J, Chen, L, Wang, TL, Stoeck, A, Shih, IeM, Thiaville, MM

Cancer Res. 2012
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Input
Output
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Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-01)
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