DLGAP5 gene transcription is stimulated by NOTCH3

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R-HSA-9018538
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of the NOTCH3 coactivator complex to RBPJ response elements in the promoter of the DLGAP5 gene stimulates DLGAP5 transcription. DLGAP5 is involved in G2/M transition and is overexpressed in ovarian cancer cells. NOTCH3 gene is frequently amplified in ovarian cancer (Chen et al. 2012).

Literature References
PubMed ID Title Journal Year
22396495 Defining NOTCH3 target genes in ovarian cancer

Chen, X, Thiaville, MM, Chen, L, Stoeck, A, Xuan, J, Gao, M, Shih, IeM, Wang, TL

Cancer Res. 2012
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