GDIs block activation of RHOC

Stable Identifier
Reaction [binding]
Homo sapiens
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ARHGDIA is a GDP dissociation inhibitor (GDI) that binds to RHOC and inhibits it (Boulter et al. 2010; Giang Ho et al. 2011). ARHGDIG does not act on RHOC (Zalcman et al. 1996).

Literature References
PubMed ID Title Journal Year
20400958 Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

Boulter, E, Garcia-Mata, R, Guilluy, C, Dubash, A, Rossi, G, Brennwald, PJ, Burridge, K

Nat. Cell Biol. 2010
21757538 RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis

Giang Ho, TT, Stultiens, A, Dubail, J, Lapière, CM, Nusgens, BV, Colige, AC, Deroanne, CF

Mol. Biol. Cell 2011
8939998 RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG

Zalcman, G, Closson, V, Camonis, J, Honoré, N, Rousseau-Merck, MF, Tavitian, A, Olofsson, B

J. Biol. Chem. 1996
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