Reactome | GDIs block activation of RHOC

GDIs block activation of RHOC

Stable Identifier

R-HSA-9013108

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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ARHGDIA is a GDP dissociation inhibitor (GDI) that binds to RHOC and inhibits it (Boulter et al. 2010; Giang Ho et al. 2011). ARHGDIG does not act on RHOC (Zalcman et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
21757538	RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis Giang Ho, TT, Dubail, J, Deroanne, CF, Lapière, CM, Colige, AC, Nusgens, BV, Stultiens, A	Mol. Biol. Cell	2011
20400958	Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1 Burridge, K, Dubash, A, Boulter, E, Brennwald, PJ, Guilluy, C, Rossi, G, Garcia-Mata, R	Nat. Cell Biol.	2010
8939998	RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG Honoré, N, Olofsson, B, Camonis, J, Rousseau-Merck, MF, Zalcman, G, Closson, V, Tavitian, A	J. Biol. Chem.	1996