Reactome | GDIs block activation of RHOC

GDIs block activation of RHOC

Stable Identifier

R-HSA-9013108

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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ARHGDIA is a GDP dissociation inhibitor (GDI) that binds to RHOC and inhibits it (Boulter et al. 2010; Giang Ho et al. 2011). ARHGDIG does not act on RHOC (Zalcman et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
21757538	RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis Giang Ho, TT, Stultiens, A, Dubail, J, Lapière, CM, Nusgens, BV, Colige, AC, Deroanne, CF	Mol. Biol. Cell	2011
20400958	Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1 Boulter, E, Garcia-Mata, R, Guilluy, C, Dubash, A, Rossi, G, Brennwald, PJ, Burridge, K	Nat. Cell Biol.	2010
8939998	RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG Zalcman, G, Closson, V, Camonis, J, Honoré, N, Rousseau-Merck, MF, Tavitian, A, Olofsson, B	J. Biol. Chem.	1996