Reactome | ME3 [mitochondrial matrix]

ME3 [mitochondrial matrix]

Stable Identifier

R-HSA-9012082

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Citric acid cycle (TCA cycle) (Homo sapiens)
      - ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)
        
        ME3:Mg2+ tetramer [mitochondrial matrix] (Homo sapiens)
        
        ME3:Mg2+ dimer [mitochondrial matrix] (Homo sapiens)
        
        ME3:Mg2+ [mitochondrial matrix] (Homo sapiens)
        
        ME3 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16798 ME3

Gene Names

ME3

Chain

transit peptide:1-, chain:-604

Reference Genes

BioGPS Gene:10873 ME3

COSMIC (genes):ME3 ME3

CTD Gene:10873 ME3

dbSNP Gene:10873 ME3

ENSEMBL:ENSG00000151376 ME3

ENSEMBL:ENSG00000151376.18 ME3

HGNC:6985 ME3

KEGG Gene (Homo sapiens):10873 ME3

Monarch:10873 ME3

NCBI Gene:10873 ME3

OMIM:604626 ME3

UCSC:Q16798 ME3

Reference Transcript

Other Identifiers

10873

11732580_a_at

11749202_a_at

11761506_at

16743056

204663_PM_at

204663_at

3385312

3385313

3385314

3385316

3385319

3385321

3385322

3385325

3385332

3385348

3385365

3385371

3385379

3385384

3385385

3385406

3385407

3385408

3385409

3385410

3385411

3385412

3385413

3385414

35216_at

7950864

A_23_P105227

A_23_P116614

GE60050

GO:0003824

GO:0004470

GO:0004471

GO:0004473

GO:0005739

GO:0005759

GO:0006090

GO:0006091

GO:0006108

GO:0008948

GO:0009060

GO:0016491

GO:0016616

GO:0016829

GO:0043226

GO:0046872

GO:0051287

GO:0070401

GO:0072592

HMNXSV003003547

HMNXSV003028603

Hs.169161.0.A1_3p_s_at

ILMN_1762445

ILMN_1793615

ILMN_1812362

PH_hs_0018322

TC11002167.hg

X79440_at

g5729919_3p_at

Participates

as a component of

ME3:Mg2+ [mitochondrial matrix] (Homo sapiens)

Inferred To

Men [mitochondrial matrix] (Drosophila melanogaster)

ME3 [mitochondrial matrix] (Bos taurus)

ME3 [mitochondrial matrix] (Caenorhabditis elegans)

ME3 [mitochondrial matrix] (Canis familiaris)

ME3 [mitochondrial matrix] (Danio rerio)

ME3 [mitochondrial matrix] (Drosophila melanogaster)

ME3 [mitochondrial matrix] (Gallus gallus)

ME3 [mitochondrial matrix] (Mus musculus)

ME3 [mitochondrial matrix] (Rattus norvegicus)

ME3 [mitochondrial matrix] (Sus scrofa)

ME3 [mitochondrial matrix] (Xenopus tropicalis)

Homologues of ME3 [mitochondrial matrix] (Drosophila melanogaster)

Cross References

RefSeq

NP_001155058.1, NP_006671.2, NP_001014811.1, XP_005273774.1

OpenTargets

ENSG00000151376

GeneCards

Q16798

HPA

ENSG00000151376-ME3

ZINC target

Q16798

Ensembl

ENST00000393324, ENST00000543262, ENSG00000151376, ENSP00000376998, ENSP00000433636, ENST00000524826, ENSP00000440246, ENSP00000431182, ENST00000526504

PRO

Q16798

Pharos - Targets

Q16798

PDB

8E76, 8E8O, 8EYN, 8E78, 8EYO

HMDB Protein

HMDBP00859