Reactome | ME3 [mitochondrial matrix]

ME3 [mitochondrial matrix]

Stable Identifier

R-HSA-9012082

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - ME3 tetramer decarboxylates MAL to PYR (Homo sapiens)
      - ME3:Mg2+ tetramer [mitochondrial matrix] (Homo sapiens)
        
        ME3:Mg2+ dimer [mitochondrial matrix] (Homo sapiens)
        
        ME3:Mg2+ [mitochondrial matrix] (Homo sapiens)
        
        ME3 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16798 ME3

Gene Names

ME3

Chain

transit peptide:1-, chain:-604

Reference Genes

BioGPS Gene:10873 ME3

COSMIC (genes):ME3 ME3

CTD Gene:10873 ME3

dbSNP Gene:10873 ME3

ENSEMBL:ENSG00000151376 ME3

HGNC:6985 ME3

KEGG:hsa:10873 ME3

Monarch:10873 ME3

NCBI Gene:10873 ME3

OMIM:604626 ME3

UCSC:Q16798 ME3

Reference Transcript

Other Identifiers

10873

11732580_a_at

11749202_a_at

11761506_at

16743056

204663_PM_at

204663_at

3385312

3385313

3385314

3385315

3385316

3385317

3385318

3385319

3385321

3385322

3385325

3385332

3385342

3385343

3385344

3385345

3385348

3385365

3385366

3385371

3385372

3385373

3385379

3385383

3385384

3385385

3385404

3385405

3385406

3385407

3385408

3385409

3385410

3385411

3385412

3385413

3385414

35216_at

7950864

A_23_P105227

A_23_P116614

GE60050

GO:0003824

GO:0004470

GO:0004473

GO:0005739

GO:0005759

GO:0006090

GO:0006091

GO:0006108

GO:0008948

GO:0009060

GO:0016491

GO:0016616

GO:0016829

GO:0043226

GO:0046872

GO:0051287

GO:0070401

GO:0072592

HMNXSV003003547

HMNXSV003028603

Hs.169161.0.A1_3p_s_at

ILMN_1762445

ILMN_1793615

ILMN_1812362

PH_hs_0018322

TC11002167.hg

X79440_at

g5729919_3p_at

Participates

as a component of

ME3:Mg2+ [mitochondrial matrix] (Homo sapiens)

Inferred To

Men [mitochondrial matrix] (Drosophila melanogaster)

ME3 [mitochondrial matrix] (Bos taurus)

ME3 [mitochondrial matrix] (Caenorhabditis elegans)

ME3 [mitochondrial matrix] (Canis familiaris)

ME3 [mitochondrial matrix] (Danio rerio)

ME3 [mitochondrial matrix] (Drosophila melanogaster)

ME3 [mitochondrial matrix] (Gallus gallus)

ME3 [mitochondrial matrix] (Mus musculus)

ME3 [mitochondrial matrix] (Rattus norvegicus)

ME3 [mitochondrial matrix] (Sus scrofa)

ME3 [mitochondrial matrix] (Xenopus tropicalis)

Homologues of ME3 [mitochondrial matrix] (Drosophila melanogaster)

Cross References

RefSeq

NP_006671.2, NP_001014811.1, XP_005273774.1, NP_001155058.1

ENSEMBL

ENSP00000440246, ENST00000543262, ENSP00000376998, ENST00000393324, ENSP00000433636, ENST00000526504

OpenTargets

ENSG00000151376

HPA

ENSG00000151376-ME3

ZINC target

Q16798

PRO

Q16798

Pharos - Targets

Q16798

HMDB Protein

HMDBP00859

PDB

8E76, 8E78, 8E8O, 8EYO, 8EYN

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