RUNX2 binds to HIVEP3 and WWP1

Stable Identifier
R-HSA-9008036
Type
Reaction [binding]
Species
Homo sapiens
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Based on studies in mice, HIVEP3 (also known as SHN3 or Schnurri-3), a zinc finger adapter protein, binds to RUNX2 together with the E3 ubiquitin ligase WWP1. Hivep3 knockout mice exhibit increased bone mass, due to increased bone formation by osteoblasts, which is accompanied by increased expression of Runx2 target genes (Jones et al. 2006).

Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Jones, DC, Wein, MN, Oukka, M, Hofstaetter, JG, Glimcher, MJ, Glimcher, LH

Science 2006
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