CBX3 and PRC1.6 associate with E2F6.com-1

Stable Identifier
R-HSA-9007283
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CBX3 (HP1gamma) and the polycomb group (PcG) repressor complex PRC1.6 associate with the E2F6.com-1 complex. The PRC1.6 complex shown to associate with E2F6 consists of PCGF6 (MBLR), RING1 (RING1A) or RNF2 (RING2, also known as RING1B), YAF2 and L3MBTL2. The E2F6.com-1 complex is composed of E2F6, TFDP1 (DP-1), MGA, MAX, EHMT1 (GLP) and EHMT2 (G9a). This complex likely has a histone H3 methyltransferase activity and may be involved in creating the repressive H3K9Me mark at target genes, which would result in transcriptional repression (Ogawa et al. 2002).

Literature References
PubMed ID Title Journal Year
12004135 A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

Ogawa, H, Ishiguro, K, Gaubatz, S, Livingston, DM, Nakatani, Y

Science 2002
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