MECP2 binds the SIN3A co-repressor complex

Stable Identifier
R-HSA-9005995
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MECP2 binds the SIN3A co-repressor complex
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MECP2 binds the SIN3A co-repressor complex. This interaction involves the transcriptional repressor domain of MECP2 and the amino-terminal part of the HDAC-interaction domain (HID) of SIN3A. HDAC1 and HDAC2 are part of the SIN3A co-repressor complex that co-immunoprecipitates with MECP2. Presence of other components of the SIN3A co-repressor complex has not been tested (Nan et al. 1998). MECP2 is not an obligate component of the SIN3A corepressor complex (Klose et al. 2004).
Literature References
PubMed ID Title Journal Year
15322089 MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex

Klose, RJ, Bird, AP

J. Biol. Chem. 2004
9620804 Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X, Ng, HH, Johnson, CA, Laherty, CD, Turner, BM, Eisenman, RN, Bird, A

Nature 1998
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Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-11)
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