p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3

Stable Identifier
R-HSA-8987236
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
p-Y705-STAT3 dissociates from the IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 activated receptor complex, STAT3 dissociates from the IL22 receptor complex
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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) dissociates from the Interleukin-22 (IL22) receptor complex, which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha 1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine protein-kinase TYK2 (TYK2) and Tyrosine protein phosphatase non receptor type 11 (PTPN11 or SHP2) and STAT3. This is a black-box event because dissociation is inferred from other interleukin signaling cascades e.g. Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006, You et al. 2013) where dissociation occurs before STAT dimerization and translocation to the nucleus.

Literature References
PubMed ID Title Journal Year
7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S, Nishio, Y, Inoue, M, Wang, XJ, Wei, S, Matsusaka, T, Yoshida, K, Sudo, T, Naruto, M, Kishimoto, T

Cell 1994
15919823 STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3

Liu, L, McBride, KM, Reich, NC

Proc. Natl. Acad. Sci. U.S.A. 2005
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