Reactome | p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3

p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3

Stable Identifier

R-HSA-8987236

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

p-Y705-STAT3 dissociates from the IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 activated receptor complex, STAT3 dissociates from the IL22 receptor complex

ReviewStatus

5/5

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p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3

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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) dissociates from the Interleukin-22 (IL22) receptor complex, which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha 1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine protein-kinase TYK2 (TYK2) and Tyrosine protein phosphatase non receptor type 11 (PTPN11 or SHP2) and STAT3. This is a black-box event because dissociation is inferred from other interleukin signaling cascades e.g. Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006, You et al. 2013) where dissociation occurs before STAT dimerization and translocation to the nucleus.

Literature References

PubMed ID	Title	Journal	Year
15919823	STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3 Reich, NC, McBride, KM, Liu, L	Proc. Natl. Acad. Sci. U.S.A.	2005
7512451	Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway Kishimoto, T, Naruto, M, Wang, XJ, Yoshida, K, Nishio, Y, Wei, S, Sudo, T, Akira, S, Matsusaka, T, Inoue, M	Cell	1994