IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

Stable Identifier
Reaction [uncertain]
Homo sapiens
JAK2, JAK3 are phosphorylated after IL20:IL20RA:JAK1:IL20RB:JAK2:JAK3 interaction, JAK2, JAK3 are phosphorylated after IL20 IL20 receptor, JAK2, JAK3 are phsophorylated after IL20 stimulus
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Tyrosine-protein kinase JAK2 (JAK2) or Tyrosine-protein kinase JAK3 (JAK3) are phosphorylated after the binding of Interleukin-20 (IL20) to a heterodimeric receptor complex formed by Interleukin-20 receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB).
JAK2 is phosphorylated at Tyr-1007/1008 (Tritsaris et al. 2007). JAK3 is also phosphorylated (Lee et al. 2012).
This is a black box event because it is unclear whether JAK2 and JAK3 are phosphorylated simultaneously or sequentially during IL20 stimulation.
Literature References
PubMed ID Title Journal Year
17878297 IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs

Jia, T, Myren, M, Olsen, UB, Hansen, AJ, van der Blom, I, Ditlev, SB, Dissing, S, Cao, Y, Zhang, J, H├╝bschmann, MV, Tritsaris, K, Cao, R, Wahlberg, E

Proc. Natl. Acad. Sci. U.S.A. 2007
22962576 Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A

Choi, YH, Jeong, P, Kim, S, Moon, SK, Kim, SK, Lee, SJ, Kim, GY, Cho, YH, Cha, EJ, Lee, EJ, Kim, WJ, Yun, SJ

PLoS ONE 2012
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane]

Orthologous Events
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