Reactome | IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

Stable Identifier

R-HSA-8987179

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

JAK2, JAK3 are phosphorylated after IL20:IL20RA:JAK1:IL20RB:JAK2:JAK3 interaction, JAK2, JAK3 are phosphorylated after IL20 IL20 receptor, JAK2, JAK3 are phsophorylated after IL20 stimulus

ReviewStatus

5/5

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IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

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Tyrosine-protein kinase JAK2 (JAK2) or Tyrosine-protein kinase JAK3 (JAK3) are phosphorylated after the binding of Interleukin-20 (IL20) to a heterodimeric receptor complex formed by Interleukin-20 receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB).
JAK2 is phosphorylated at Tyr-1007/1008 (Tritsaris et al. 2007). JAK3 is also phosphorylated (Lee et al. 2012).
This is a black box event because it is unclear whether JAK2 and JAK3 are phosphorylated simultaneously or sequentially during IL20 stimulation.

Literature References

PubMed ID	Title	Journal	Year
17878297	IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs Tritsaris, K, Myren, M, Ditlev, SB, Hübschmann, MV, van der Blom, I, Hansen, AJ, Olsen, UB, Cao, R, Zhang, J, Jia, T, Wahlberg, E, Dissing, S, Cao, Y	Proc. Natl. Acad. Sci. U.S.A.	2007
22962576	Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A Lee, SJ, Lee, EJ, Kim, SK, Jeong, P, Cho, YH, Yun, SJ, Kim, S, Kim, GY, Choi, YH, Cha, EJ, Kim, WJ, Moon, SK	PLoS ONE	2012