Reactome | IL20 binds IL20RA:JAK1:IL20RB

IL20 binds IL20RA:JAK1:IL20RB

Stable Identifier

R-HSA-8987015

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

IL20 binds IL20RA:JAK1:IL20RB receptor complex

ReviewStatus

5/5

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Interleukin-20 (IL20) binds a heterodimeric receptor complex that consists of Interleukin-20 receptor subunit alpha (IL20RA), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). Interleukin-20 receptor A (IL20RA) and Interleukin-20 receptor B (IL20RB) form a receptor complex for Interleukin-20 (IL20), Interleukin-19 (IL19) and Interleukin-24 (IL24) (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). IL20 can also bind a receptor complex that consists of Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Kolumam et al. 2017). As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain black box event.

Literature References

PubMed ID	Title	Journal	Year
22802649	Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines Logsdon, NJ, Rajashankar, KR, Harris, BD, Deshpande, A, Walter, MR	Proc. Natl. Acad. Sci. U.S.A.	2012
11163236	Interleukin 20: discovery, receptor identification, and role in epidermal function Sexson, S, Parrish-Novak, J, Dale, BA, Xu, WF, Eagan, M, Yao, L, Madden, K, Carollo, S, Prunkard, D, Kuechle, MK, Whitmore, TE, Kelly, JD, Hammond, A, Blumberg, H, Foster, D, Sprecher, C, Chandrasekher, YA, Jelinek, L, Brender, T, Grossmann, A, Conklin, D, Haugen, H, West, J, Haldeman, BA, Waggie, K, Maurer, MF	Cell	2001
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W	J Biol Chem	2002