IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

Stable Identifier
R-HSA-8986995
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
IL22RA is phosphorylated by IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 activated receptor complex, IL22RA is phosphorylated after IL22-IL22 receptor complex, IL22:p?Y251,p?Y301?IL22RA1:p?JAK1:PTPN11:IL10RB:p?TYK2 phosphorylates PTPN11
Locations in the PathwayBrowser
Summation

Interleukin-22 receptor subunit alpha-1 (IL22RA1) is phosphorylated within the receptor complex, which consists of Interleukin-22 (IL22), IL22RA1 associated with phosphorylated Tyrosine protein kinase JAK1 (JAK1) and Interleukin-10 receptor subunit beta (IL10RB) associated with phosphorylated non-receptor tyrosine-protein kinase TYK2 (TYK2). IL22 stimulated IL22RA1 tyrosine phosphorylation and recruitment of Tyrosine protein phosphatase non receptor type 11 (PTPN11, SHP2). PTPN11 binding was abolished by mutation of Tyrosines-251 and 301 (Meng et al. 2010).
This is a black-box event because it is not clear which kinase is responsible for IL22RA1 phosphorylation.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events