Interleukin-22 receptor subunit alpha-1 (IL22RA1) is phosphorylated within the receptor complex, which consists of Interleukin-22 (IL22), IL22RA1 associated with phosphorylated Tyrosine protein kinase JAK1 (JAK1) and Interleukin-10 receptor subunit beta (IL10RB) associated with phosphorylated non-receptor tyrosine-protein kinase TYK2 (TYK2). IL22 stimulated IL22RA1 tyrosine phosphorylation and recruitment of Tyrosine protein phosphatase non receptor type 11 (PTPN11, SHP2). PTPN11 binding was abolished by mutation of Tyrosines-251 and 301 (Meng et al. 2010).This is a black-box event because it is not clear which kinase is responsible for IL22RA1 phosphorylation.
transmembrane receptor protein tyrosine kinase activity of IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]