Reactome | IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

Stable Identifier

R-HSA-8986995

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

IL22RA is phosphorylated by IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 activated receptor complex, IL22RA is phosphorylated after IL22-IL22 receptor complex, IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 phosphorylates PTPN11

ReviewStatus

5/5

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IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

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Interleukin-22 receptor subunit alpha-1 (IL22RA1) is phosphorylated within the receptor complex, which consists of Interleukin-22 (IL22), IL22RA1 associated with phosphorylated Tyrosine protein kinase JAK1 (JAK1) and Interleukin-10 receptor subunit beta (IL10RB) associated with phosphorylated non-receptor tyrosine-protein kinase TYK2 (TYK2). IL22 stimulated IL22RA1 tyrosine phosphorylation and recruitment of Tyrosine protein phosphatase non receptor type 11 (PTPN11, SHP2). PTPN11 binding was abolished by mutation of Tyrosines-251 and 301 (Meng et al. 2010).
This is a black-box event because it is not clear which kinase is responsible for IL22RA1 phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
20671117	Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation Meng, S, Gui, Q, Xu, Q, Lu, K, Jiao, X, Fan, J, Ge, B, Ke, Y, Zhang, S, Wu, J, Wang, C	J Mol Cell Biol	2010