IL24 binds IL20RA:JAK1:IL20RB

Stable Identifier
Reaction [uncertain]
Homo sapiens
IL24 binds to IL20RA:JAK1:IL20RB receptor complex, IL20RA:IL20RB binds IL24
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Interleukin-24 (IL24) binds a receptor complex containing Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) (Andoh et al. 2009, Logsdon et al. 2012) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish Novak et al.1998). Furthermore IL24 can also bind Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Wang et al. 2002) to form a ligand receptor complex.
As it is not clear whether the receptor complex can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.
Literature References
PubMed ID Title Journal Year
11706020 Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2

Liang, P, Zhang, R, Wang, M, Tan, Z, Kotenko, SV

J. Biol. Chem. 2002
22802649 Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines

Logsdon, NJ, Rajashankar, KR, Harris, BD, Deshpande, A, Walter, MR

Proc. Natl. Acad. Sci. U.S.A. 2012
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W

J Biol Chem 2002
Orthologous Events
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