The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter

Stable Identifier
R-HSA-8985227
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter
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Based on studies in mouse cells, the complex of RUNX2 and WWTR1 (TAZ) binds to the promoter of the BGLAP gene, encoding osteocalcin (Hong et al. 2005). Catalytically active protein tyrosine kinase ABL1 promotes association of RUNX2 and WWTR1 and transcription of the BGLAP gene (Matsumoto et al. 2016). RUNX2 binding sites are conserved in the human BGLAP gene promoter.
Literature References
PubMed ID Title Journal Year
16099986 TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

Hong, JH, Hwang, ES, McManus, MT, Amsterdam, A, Tian, Y, Kalmukova, R, Mueller, E, Benjamin, T, Spiegelman, BM, Sharp, PA, Hopkins, N, Yaffe, MB

Science 2005
27797343 Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2

Matsumoto, Y, La Rose, J, Kent, OA, Wagner, MJ, Narimatsu, M, Levy, AD, Omar, MH, Tong, J, Krieger, JR, Riggs, E, Storozhuk, Y, Pasquale, J, Ventura, M, Yeganeh, B, Post, M, Moran, MF, Grynpas, MD, Wrana, JL, Superti-Furga, G, Koleske, AJ, Pendergast, AM, Rottapel, R

J. Clin. Invest. 2016
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Output
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as an event of
This event is regulated
Positively by
Regulator
p-Y226,Y393-ABL1 [nucleoplasm] (Homo sapiens)
Inferred From
Runx2:Wwtr1 binds the Bglap gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-04-13)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-04-13)
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