IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5

Stable Identifier
R-HSA-8983378
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription 3 (STAT3), Signal transducer and activator of transcription 5A and 5B (STAT5) are believed to bind the Interleukin-15 (IL15) receptor complex, which consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). This is a black-box event because STAT binding is inferred from their subsequent phosphorylation.

Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Johnston, JA, Bacon, CM, Finbloom, DS, Rees, RC, Kaplan, D, Shibuya, K, Ortaldo, JR, Gupta, S, Chen, YQ, Giri, JD

Proc Natl Acad Sci U S A 1995
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