Signal transducer and activator of transcription 3 (STAT3), Signal transducer and activator of transcription 5A and 5B (STAT5) are believed to bind the Interleukin-15 (IL15) receptor complex, which consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). This is a black-box event because STAT binding is inferred from their subsequent phosphorylation.
Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC
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