G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC

Stable Identifier
R-HSA-8964252
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC
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G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAS) can directly bind to SRC. In the presence of active GNAS, SRC can autophosphorylate the 419-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm.
Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Ma, YC, Huang, J, Ali, S, Lowry, W, Huang, XY

Cell 2000
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Output
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Catalyst Activity

protein tyrosine kinase activity of G alpha (s):GTP:SRC [plasma membrane]

Physical Entity
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Authored
Varusai, TM  (2017-07-27)
Reviewed
Huang, X  (2018-09-13)
Created
Varusai, TM  (2017-02-16)
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