Reactome | BTK in G alpha (12)-BTK complex is activated

BTK in G alpha (12)-BTK complex is activated

Stable Identifier

R-HSA-8964246

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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BTK in G alpha (12)-BTK complex is activated

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind the non-receptor Tyrosine-protein kinase BTK. In this complex, GNA12 triggers BTK activation. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References

PubMed ID	Title	Journal	Year
9796816	The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain Jiang, Y, Ma, W, Wan, Y, Kozasa, T, Hattori, S, Huang, XY	Nature	1998
11742120	Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH	Protein Sci.	2002