CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2

Stable Identifier
R-HSA-8961934
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1 directly stimulates transcription of the CDK1 gene, encoding cyclin-dependent kinase 1 (Cdc2) (Furukawa et al. 1994, DeGregori et al. 1995, Zhu et al. 2004). Transcription of the CDK1 gene is directly inhibited by complexes of HDAC1 and RBL1 (p107) or RBL2 (p130) in G1 and G0, respectively (Rayman et al. 2002).
Literature References
PubMed ID Title Journal Year
15510213 E2Fs link the control of G1/S and G2/M transcription

Zhu, W, Giangrande, PH, Nevins, JR

EMBO J. 2004
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Rayman, JB, Takahashi, Y, Indjeian, VB, Dannenberg, JH, Catchpole, S, Watson, RJ, te Riele, H, Dynlacht, BD

Genes Dev 2002
7929342 The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells

Furukawa, Y, Terui, Y, Sakoe, K, Ohta, M, Saito, M

J. Biol. Chem. 1994
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm]
Positively by
Regulator
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Inferred From
Cdk1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1 (Mus musculus)
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-06)
Cite Us!