CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2

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R-HSA-8961934
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Reaction [omitted]
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Homo sapiens
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E2F1 directly stimulates transcription of the CDK1 gene, encoding cyclin-dependent kinase 1 (Cdc2) (Furukawa et al. 1994, DeGregori et al. 1995, Zhu et al. 2004). Transcription of the CDK1 gene is directly inhibited by complexes of HDAC1 and RBL1 (p107) or RBL2 (p130) in G1 and G0, respectively (Rayman et al. 2002).

Literature References
PubMed ID Title Journal Year
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Rayman, JB, Takahashi, Y, Indjeian, VB, Dannenberg, JH, Catchpole, S, Watson, RJ, te Riele, H, Dynlacht, BD

Genes Dev 2002
15510213 E2Fs link the control of G1/S and G2/M transcription

Zhu, W, Giangrande, PH, Nevins, JR

EMBO J. 2004
7929342 The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells

Furukawa, Y, Terui, Y, Sakoe, K, Ohta, M, Saito, M

J. Biol. Chem. 1994
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
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