CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F1 directly stimulates transcription of the CDK1 gene, encoding cyclin-dependent kinase 1 (Cdc2) (Furukawa et al. 1994, DeGregori et al. 1995, Zhu et al. 2004). Transcription of the CDK1 gene is directly inhibited by complexes of HDAC1 and RBL1 (p107) or RBL2 (p130) in G1 and G0, respectively (Rayman et al. 2002).

Literature References
PubMed ID Title Journal Year
15510213 E2Fs link the control of G1/S and G2/M transcription

Nevins, JR, Zhu, W, Giangrande, PH

EMBO J. 2004
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Catchpole, S, Dynlacht, BD, te Riele, H, Dannenberg, JH, Watson, RJ, Rayman, JB, Indjeian, VB, Takahashi, Y

Genes Dev 2002
7929342 The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells

Saito, M, Furukawa, Y, Sakoe, K, Ohta, M, Terui, Y

J. Biol. Chem. 1994
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

Nevins, JR, DeGregori, J, Kowalik, T

Mol Cell Biol 1995
This event is regulated
Inferred From
Cite Us!