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E2F1 binds the CCNA1 gene promoter
Stable Identifier
R-HSA-8961888
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
E2F1 binds the CCNA1 gene promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1 binds to E2F binding sites in the promoter of the CCNA1 gene, encoding cyclin A1 (DeGregori et al. 1995, Liu et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
7623816
Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
Nevins, JR
,
DeGregori, J
,
Kowalik, T
Mol Cell Biol
1995
9662327
A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F
Müller, R
,
Engeland, K
,
Lucibello, FC
,
Liu, N
Oncogene
1998
Participants
Input
CCNA1 gene [nucleoplasm]
(Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Homo sapiens)
Output
E2F1:TFDP1,TFDP2:CCNA1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
G1/S-Specific Transcription (Homo sapiens)
Authored
Gopinathrao, G (2004-06-16)
Reviewed
Bosco, G (2004-06-16)
Created
Orlic-Milacic, M (2017-02-06)
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