E2F1 binds the ORC1 gene promoter

Stable Identifier
R-HSA-8961671
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

E2F1 binds to E2F binding sites in the promoter of the ORC1 gene (Ohtani et al. 1996, Ohtani et al. 1998). It has been observed in Drosophila that E2F1 regulated expression of Orc1 stimulates ORC1-6 complex formation and binding to the origin of replication (Asano and Wharton, 1999).

Literature References
PubMed ID Title Journal Year
8943353 Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

Ohtani, K, DeGregori, J, Leone, G, Herendeen, DR, Kelly, TJ, Nevins, JR

Mol Cell Biol 1996
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Tsujimoto, A, Ikeda, M, Nakamura, M

Oncogene 1998
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