Reactome | Metabolism of steroids

Metabolism of steroids

Stable Identifier

R-HSA-8957322

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Steroids, defined by a four-ring cyclopenta[a]phenanthrene carbon skeleton, include cholesterol and bile acids and salts, steroid hormones, and vitamin D, three groups of molecules synthesized from it. In this module, pathways for the synthesis of cholesterol from HMG-CoA (hydroxymethylglutaryl-coenzyme A) (Russell 1992), and for its conversion to bile acids and salts (Russell 2003), steroid hormones (Payne & Hales 2004), and vitamin D (Dusso et al. 2005) are annotated, together with the SREBP-mediated regulatory process that normally links the rate of cholesterol synthesis to levels of cellular cholesterol (Brown & Goldstein 2009).

Literature References

PubMed ID	Title	Journal	Year
15951480	Vitamin D Slatopolsky, E, Brown, AJ, Dusso, AS	Am J Physiol Renal Physiol	2005
18974038	Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL Brown, MS, Goldstein, JL	J Lipid Res	2009
1390320	Cholesterol biosynthesis and metabolism Russell, DW	Cardiovasc Drugs Ther	1992
15583024	Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Payne, AH, Hales, DB	Endocr Rev	2004
12543708	The enzymes, regulation, and genetics of bile acid synthesis Russell, DW	Annu Rev Biochem	2003