Metabolism of steroids

Stable Identifier
Homo sapiens
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Steroids, defined by a four-ring cyclopenta[a]phenanthrene carbon skeleton, include cholesterol and bile acids and salts, steroid hormones, and vitamin D, three groups of molecules synthesized from it. In this module, pathways for the synthesis of cholesterol from HMG-CoA (hydroxymethylglutaryl-coenzyme A) (Russell 1992), and for its conversion to bile acids and salts (Russell 2003), steroid hormones (Payne & Hales 2004), and vitamin D (Dusso et al. 2005) are annotated, together with the SREBP-mediated regulatory process that normally links the rate of cholesterol synthesis to levels of cellular cholesterol (Brown & Goldstein 2009).

Literature References
PubMed ID Title Journal Year
18974038 Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

Brown, MS, Goldstein, JL

J Lipid Res 2009
15951480 Vitamin D

Dusso, AS, Brown, AJ, Slatopolsky, E

Am J Physiol Renal Physiol 2005
1390320 Cholesterol biosynthesis and metabolism

Russell, DW

Cardiovasc Drugs Ther 1992
15583024 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

Payne, AH, Hales, DB

Endocr Rev 2004
12543708 The enzymes, regulation, and genetics of bile acid synthesis

Russell, DW

Annu Rev Biochem 2003
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